Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. Aβ accumulation in the brain is proposed ...

Researchers at Brown University and the Marine Biological Laboratory at Woods Hole, Mass., have found a physical connection between the herpes simplex virus and amyloid precursor protein, a protein ...

Unlike treatments that focus on removing plaques that have already formed, levetiracetam works differently. It blocks the ...

β-Secretase (BACE, Asp-2) is a transmembrane aspartic proteinase responsible for cleaving the amyloid precursor protein (APP) to generate the soluble ectodomain ...

There are many unknowns around the causes of Alzheimer's, but one of the leading suspects is amyloid beta plaques. These form from amyloid peptides, and while some see these biomarkers as a chance to ...

Alzheimer’s disease can be either sporadic or familial, with common mutations found in amyloid precursor protein (APP) and presenilin genes. The condition can be further classified based by the age of ...

The amyloid protein conformation, a structure that propagates as insoluble fibrils of aggregated β-strand-containing peptides, is a common feature of many neurodegenerative diseases. In Alzheimer, ...

(A, B) ALP staining and activity detection were performed after treating cells with APPswe or BMP2 for 5 days or 7 days. (C, D) ARS staining and semiquantitative analysis were used to detect calcium ...