A new advance overcomes present limitations in spatial transcriptomics with a DNA nanotechnology-driven method called 'Light-Seq.' Light-Seq allows researchers to 'geotag' the full repertoire of RNA ...

A new spatial transcriptomics technology—the DNA nanotechnology-driven method called “Light-Seq”—allows researchers to “geotag” the full repertoire of RNA sequences with unique DNA barcodes exclusive ...

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems. Now an interdisciplinary ...

Janelia researchers developed an innovative new technique – cycleHCR -- that uses a novel DNA barcode system to track hundreds of RNA and protein molecules in single cells within thick biological ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

For the Liu Lab, necessity is truly the mother of invention. The researchers were examining how the 3D organization of the genome controls development and needed to image hundreds of RNA molecules in ...

Stay up to date on the latest science with Brush Up Summaries. Article reviewed by Ninning Liu, PhD from the Wyss Institute at Harvard University. Similar to retail stores that use standardized ...

Genes have to be expressed in the right place, at the time, and at the right levels to carry out the right functions. To learn more about these physiological processes and how they change in disease, ...