Repeat proteins, defined by sequential arrays of short structural motifs, offer an intriguing departure from the folding behaviour of conventional globular proteins. Their modular architecture enables ...

Researchers have found a new common thread linking nearly all of the trinucleotide repeat expansion diseases, which include ALS, Huntington's Disease and Fragile X Syndrome, involving the complicated ...

Expansion of CAG repeats beyond a threshold of 35–40 glutamines in the majority of patients is a common feature of polyglutamine disorders (reviewed in Cummings and Zoghbi 2000). The nature of the ...

The unusual folding pattern of PGK was first observed experimentally over 25 years ago. Whereas most proteins fit the "two-state" model of exponential folding kinetics, the molecules of PGK followed a ...