Protein aggregation is mostly viewed as deleterious and irreversible causing several pathologies. However, reversible protein aggregation has recently emerged as a novel concept for cellular ...

Cellular systems for protein quality control act to refold or degrade misfolded proteins, thereby preventing protein aggregation. Stress conditions and ageing can lead to an exhaustion of this ...

Immobilizing the antibodies on a solid-phase support, such as a resin, and carrying out the conjugation of the payload-linker while the antibodies are bound to that support will prevent aggregation at ...

For some manufacturers, the goal was to be fully compliant with the DSCSA, including both serialization and aggregation, from day one. Enacted by Congress on Nov. 27, 2013, the US Drug Supply Chain ...