Organs often have fluid-filled spaces called lumens, which are crucial for organ function and serve as transport and delivery ...

Pancreatic cancer is a rare disease; however, its initially inconspicuous symptoms and aggressive nature make it one of the ...

Working with three-dimensional pancreatic models (organoids), derived from mouse cells, researchers combined computer simulations with experiments to find out what controls the shape of lumens ...

Researchers have determined what affects lumen shape in pancreatic organoids, leading to the development of more accurate ...

Hans Clevers, PhD, has been working on organoids from the beginning. He was group leader for twenty years at the Hubrecht Institute and has been head of pharma research and early development (pRED) of ...

Pancreas development in pigs resembles humans much more closely than does the established mouse model. An international team headed by Helmholtz Munich and the German Center for Diabetes Research (DZD ...

Understanding how the human pancreas develops is crucial to allow scientists to make insulin producing–beta cells in the quest to cure Type 1 diabetes. Now, scientists have made a unique and ...

Pancreatic cancer is one of the deadliest forms of cancer. This is largely due to the cancer being detected at a late stage. In addition, treatment options for pancreatic cancer are limited. Therefore ...

Pancreas development in pigs resembles humans much more closely than does the established mouse model. An international team headed by Helmholtz Munich and the German Center for Diabetes Research (DZD ...

An organoid containing all three pancreatic cell lineages has been developed for the first time, providing a clearer picture of how the pancreas develops. Organoids can help us better understand ...