In-line buffer management markedly reduced the production bottlenecks and manufacturing costs inherent in biopharmaceutical manufacturing. Additional cost reductions are possible, however, by ...

Antibodies are subject to instability issues due to chemical and physical instabilities and these effects can change the pharmacokinetics of the antibody. For this reason, produced antibodies must be ...

This lab includes the complete titration procedure used to investigate how well a buffer resists changes in pH. Prepare a buffer solution by accurately calculating and measuring the required amounts ...

Process liquids and buffers are necessary tools for biotherapeutic manufacturing. In small-scale process development scales, these liquids are often overlooked as the focus is usually on the molecule, ...

This lab includes a theoretical explanation of how buffers work and how they are made, including a derivation of the Henderson-Hasselbalch equation. Students will use what they have learned to ...