In amyotrophic lateral sclerosis and frontotemporal dementia, the nuclear RNA-binding proteins TDP-43 and FUS mislocalize to cytoplasm, where they aggregate and contribute to pathology. Because both ...

The TDP-43 RNA-binding protein is found in abnormal cytoplasmic inclusions in affected motor neurons in almost all ALS cases, and mutations in the TDP-43 gene (TARDBP) cause a rare form of familial ...

Neuronal TDP-43 pathology marks most cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but how does a single protein fit with such a wide range of symptoms? Researchers ...

VectorY Therapeutics Receives FDA Clearance of IND to Proceed with the PIONEER-ALS Phase 1/2 Trial of VTx-002, a First-in-Class Vectorized Antibody Targeting TDP-43 Pathology in ALS VectorY ...