No, you'd just need to remove the HID class drivers, for example. So disallow HID_DEVICE, HID_DEVICE_SYSTEM_MOUSE and HID_DEVICE_SYSTEM_KEYBOARD. This would, if I'm following Coleman's link right, ...
If the USB ports of your system remain powered after shutdown, follow the suggestions provided below. Before you proceed, turn off the main power or disconnect the charger (if you are a laptop user).
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