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The two children of Louise of Savoy [1476 – 1531] and her husband, Charles, Count of Angoulême [1459 – 1496], Francis and Marguerite, would change the course of French history. Louise was a formidable woman politically, often acting as regent on Francis’ behalf. She ruled as regent in 1515 and again from 1525 -1526, when Francis was a prisoner in Spain. She was the principle negotiator of the Treaty of Cambrai, effectively ending the war between the Valois, Francis and Charles V the Holy Roman E